We've seen quite a few powerful Devil Fruits in the world over the years One piece. While all Devil Fruits make the user stronger in one way or another, the way they do this varies from fruit to fruit. Some fruits and grant powers that remain active at all times, while others must be activated. At the same time, some fruits tend to deplete the stamina of their users, while others simply do not affect it at all. There are quite a few devil fruits in it One piece which are known to be overkill but also negatively affect users and drain them when overused. These Devil Fruits, while rare, can actually be a double-edged sword in more ways than one.

One Piece: The Devil Fruits of Every Top-Tier Pirate, Ranking
These top level pirates are powerful and have some of the strongest Devil Fruits in One Piece.
7
Wapu Wapu no Mi
Wapu Wapu no Mi is a rather powerful type of Paramecia Devil Fruit eaten by none other than Van Augur, Sniper of the Blackbeard Pirates. This devil fruit allows Van Augur to instantly warp himself and those he touches to any location nearby, presumably nearby.
Warp forces have always been overpowered in fiction, and this is no exception. However, Van Augur tottering around people with him certainly takes its toll. It drains his stamina and at the same time his mastery of this devil fruit is not good enough to function properly. In the Egghead arc, Van Augur himself confirmed the fact that he had not yet fully trained his Devil Fruit skills and that with more mastery he would be able to use them more effectively. For now, it drains him too much to use multiple times in a row.
6
Urouge's Devil Fruit
Urouge's Devil Fruit is unlike any that fans have seen One pieceand also vary widely in how it exhausts the user. It is likely that this fruit does not drain its power when activated. Instead, Urouge must be beaten for this power to work properly. Once he takes enough damage, he can convert that damage into his power and fire them at his enemies, but this time the damage is many times greater.
Urouge's power seems to be centered around the concept of karma, and that's certainly an overpowering ability. However, it should be kept in mind that Urouge will definitely take a lot of damage when beaten, and in that sense, this devil fruit makes him suck. When the damage is too great, Urouge can be knocked out, preventing him from fully utilizing his abilities.
5
Jiki Jiki no Mi
To Jiki Jiki no Mi is Eustace Kid's Devil Fruit and it's a pretty interesting ability to hold. This fruit gives Kid the ability to control magnetism at will, and this power will certainly come in handy during his pirate journey. While regularly using this devil fruit doesn't drain him that much, it's waking up that causes him trouble.
According to Kid, he hasn't mastered his awakening yet. In addition, he also only uses his awakening as a last resort, simply because he hasn't mastered that aspect of his fruit yet and uses too much energy to even activate.

One Piece officially sets up the main performance for Loki
One Piece's Accursed Prince Loki uses the Devil Fruit Nidhoggr and a new power is in store for him in the climax of the Elbaf arc.
4
Tori Tori no Mi, Model: Phoenix
Tori Tori no Mi, Model: Phoenix is one of the most incredible Devil Fruits that belongs to the Mythical Zoan class and was eaten by the former commander of the first division of the Whitebeard Pirates, Marco. This Devil Fruit is incredible as it allows him to transform into a Phoenix and Human-Phoenix hybrid at will. This also gives Marco access to the blue flames of resurrection, which can heal all injuries in seconds, especially when it comes to his own body.
However, using blue flames of resurrection costs immense stamina. The more Marco heals, the lower his stamina and of course the harder it is for him to heal. Marco is the master of this devil fruit; however, healing certainly comes at a cost, and in the end he can no longer heal.
3
Yami Yami no Mi
Yami Yami no Mi is said to be the strongest Logia Devil Fruit, and according to Blackbeard, this Devil Fruit is the ultimate power that chose him. Yami Yami no Mi allows Blackbeard to control infinite darkness at will. On the surface, it doesn't look like an ability that actually drains Blackbeard in any way. But being a Logia, the fruit has its own adverse effects as it removes Blackbeard's intangibility and leaves him open to attack. Additionally, this not only leaves him open to attack, but also causes him to take significantly more damage from any hit he takes.
In this sense, this fruit is actually quite challenging; however, since Blackbeard has a body that can absorb damage like a sponge, it's a perfect match for him, and the benefits it provides are definitely worth it.
2
Ope Ope no Mi
Trafalgar Law's Ope Ope no Mi is one of the most incredible Paramecia Devil Fruits, allowing him to create ROOMS and manipulate almost anything inside. This Devil Fruit is pretty amazing; however, even activating the ROOM costs Law quite a lot of stamina. Furthermore, now that the Law has awakened this Devil Fruit, harnessing its powers is even more challenging than before, making it one of the most exhausting Devil Fruits in the world. One piece.
1
Hito Hito no Mi, Model: Nika
Luffy's Hito Hito no Mi, Model: Nika exhausts her powers in many ways. Normally, this Devil Fruit does not drain Luffy at all. However, when Luffy starts using more complex abilities like Gear Second, Gear Third, and Gear Fourth, his stamina takes quite a hit.
Plus, using the Awakening power will burn through his stamina pretty quickly. Luffy can't hold Gear 5 for long, and if he uses it for too long, he can even kill himself, which was proven in the fight against Kaido. Luffy's body ages rapidly when he deactivates this transformation, indicating that the toll it takes on him is absolutely immense. While the power it offers is immense and allows Luffy to even defeat Kaid, the drawbacks are significant enough to sometimes even require luck to survive as seen in Egghead.
One Piece by Eiichiro Oda is available to read through Manga Plus and Viz Media.