latest Resident Evil: Requiem the trailer is packed with new details. Some more insight into villain Victor Gideon's experiments, hints at Grace's mysterious past, and confirmation that Leon Kennedy is suffering from a mysterious infection took center stage. as a result Resident Evil: Requiem looks like it could be one of the most ambitious entries in the series. With two protagonists and a mix of tense survival horror and in-your-face action, fans will get the best of both worlds.
As exciting as Leon's return is, his infection is definitely cause for concern for his fate. Leon is infected with something called Latent On-Set T-Virus Syndrome or Raccoon City Syndrome. Resident Evil: RequiemThe fourth trailer showed several of Leon's symptoms, confirming that he is in a race against time. Only a few details are known about Raccoon City Syndrome at this point, but it's already clear that the disease is definitely not a walk in the park.
Raccoon City Syndrome means Leon isn't just fighting zombies to stay alive
The outbreak of Raccoon City is one of the most important parts Resident EvilIt's a lore, so expanding its meaning through a late-onset illness related to tragedy is a fascinating path for the story to take. This makes Leon's return to Raccoon City all the more poignant. No matter what Leon does, he cannot escape the events of Raccoon City. Now it is literally eating away at his body and he has no way of knowing if he will survive.
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Symptoms of Raccoon City Syndrome
- Phase 0: The virus lies dormant in the body of an infected person.
- Phase 1: The virus becomes active, resulting in the formation of black lesions on the body with discomfort and coughing.
- Phase 2: The black lesions spread, possibly to the organs, while the affected parts of the body are numb.
- Phase 3: At this stage the disease becomes terminal. Black spots spread throughout the body and are accompanied by intense pain that makes movement difficult. This stage eventually results in the infected person vomiting blood uncontrollably, with death occurring in less than two hours.
Leon has black spots, which means he's probably in stage 1 or stage 2. Other than that, he's only really known to investigate deaths that appear to be caused by the disease. In the opening of Trailer 4, Leon says, “That's six now. Six survivors of Raccoon City, all dead to the same thing.” Almost everyone Resident Evil the game has its mysteries to solve, but there's no denying how interesting and personal this one is.
Leon probably isn't the only returning character with Raccoon City syndrome
Although her face has not yet been fully revealed, the woman speaking to Leon from a distance looks like Sherry Birkin. Leon wears gloves to hide his black lesions and Sherry is also shown wearing gloves. This could mean he also suffers from Raccoon City syndrome. He also says, “We're running out of time, Leon,” and that gives even more weight to the possibility that Leon isn't just investigating the disease for himself, but for Sherry as well.
Victor Gideon's experiments could lead to answers on how to survive Raccoon City Syndrome
Good Resident Evil the story wouldn't be complete without some connection to the Umbrella Corporation. Introduce Victor Gideon, the main antagonist that Leon and Grace face. After Umbrella disbanded, Gideon purchased Rhodes Hill Chronic Care Center to continue his experiments. Working directly on Umbrella's Tyrant Project, Gideon eventually discovered the latent strain of the T-Virus that is the culprit behind the Raccoon City Syndrome.
Rhodes Hill Chronic Care seems to be where Leon and Grace finally cross paths. Gideon believes that Grace Ashcroft is the key to releasing the mysterious Elpis. Beyond Raccoon City Syndrome, Resident Evil: Requiem's Elpis is one of the biggest questions yet to be answered. Grace's blood is somehow the key to unleashing Elpis, and it must be something terrifying.
Resident Evil: Requiem tells a story nearly 30 years in the making
It's been 28 years since Leon first recruited for the Racoon City Police Department. A lot has happened since then and I have a feeling Resident Evil: Requiem will be a turning point for the series. Over the years, Resident Evil the franchise has a habit of leaving a lot of plot threads hanging loose and Requiem he feels it might finally bring some things full circle. With Leon and Sherry dealing with Raccoon City syndrome nearly three decades later, they may not be the only famous faces suffering from the disease.
There may be more and more surprises in Resident Evil: Requiem
Leon and Sherry are back, but they certainly weren't the only series heroes present during the Raccoon City outbreak. Claire Redfield, Jill Valentine, Ada Wong, and Carlos Oliveira were also there, so there's a chance they're all dealing with the latent T-Virus. IN Resident Evil 3Carlos gives an infected Jill a cure for the T-Virus, so she's most likely fine. But the same cannot be said about the others.
There are already theories that Leon will die Resident Evil: Requiembut it could be a red herring. Leon confirms in Trailer 4 that six survivors of Raccoon City have died of the disease, and those victims are hopefully none of the above characters. Killing off such beloved characters off-screen would be incredibly controversial, so it's less likely. However, there is still a chance for old faces to return. Fortunately for the wait Resident Evil: Requiem it's almost over so all will be revealed soon.
- Released
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February 27, 2026
- ESRB
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Mature 17+ / Intense violence, blood and gore, strong language, in-game purchases